• Xiaoting Zhang, PhD
  • Associate Professor
  • Academic Office:
    Vontz Center for Molecular Studies
    3125 Eden Avenue
    ML 0521
    Cincinnati, OH 45267
  • Phone: 513-558-3017
  • Email:

    Research/Clinical Interests:

  • Mechanisms of transcriptional and epigenetic regulation of gene expression in breast cancer and development of RNA-based nanotherapuetics.


  • Bachelor's Degree: Zhejiang University, 1993
  • Master's Degree: Fudan University, 1996
  • Doctoral Degree: The University of Iowa, 2001
  • Fellowship: Rockefeller University, 2007

Peer Reviewed Publications (in chronological order):

  • Leonard M, Zhang Y and Zhang X. (2015). Small non-coding RNAs and aptamers in diagnostics and therapeutics . Methods in Molecular Biology , 1296 , 225-33.
  • Zhang L, Cui J, Leonard M, Nephew K, Li Y, & Zhang X (2013). Silencing MED1 Sensitizes Breast Cancer Cells to pure Anti-estrogen Fulvestrant Therapy in vitro and in vivo . PLoS ONE , 8(7): e70641.
  • Germer, K., Leonard, M., & Zhang, X. (2013). RNA aptamers and their therapeutic and diagnostic applications. . International Journal of Biochemistry and Molecular Biology , 4 (1) , 27-40.
  • Cui J, Germer K, Wu T, Wang J, Luo J, Wang SC, Wang Q, and Zhang X (2012). Cross-talk Between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells . Cancer Research , 72 (21) , 5625-34.
  • Pfaff D, Waters J, Kahn I, Zhang X and Numan M. (2011). Estrogen receptor-initiated mechanisms causal to mammalian reproductive behaviors. . Endocrinology , 152 (4) , 1209-17.
  • Zhang D, Jiang P, Xu Q, and Zhang X (2011). ARGLU1 interacts with MED1 and is required for estrogen receptor-mediated transcription and breast cancer cell growth. . Journal of Biological Chemistry , 286(20):17746-54.
  • Chen Z, Zhang C, Wu D, Rorick A, Zhang X, and Wang Q (2011). Specific phosphorylation of coactivator Mediator 1coding for UBE2C locus looping leads to androgen receptor negative prostate cancer growth . EMBO J. , 30(12):2405-19.
  • Zhang, D., Jiang, P., Xu, Q., & Zhang, X. (2011). Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. . The Journal of Biological Chemistry , 286 (20) , 17746-54.
  • Jiang, P., Hu, Q., Ito, M., Meyer, S., Waltz, S., Khan, S., Roeder, R. G., & Zhang, X. (2010). Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation . Proc Natl Acad Sci U S A , 107 (15 ) , 6765-70.
  • Chen, W., Zhang, X., Birsoy, K., & Roeder, R. G. (2010). A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism . Proc Natl Acad Sci U S A , 107 (22 ) , 10196-201.
  • Jiang, P., Hu, Q., Ito, M., Meyer, S., Waltz, S., Khan, S., Roeder, R. G., & Zhang, X. (2010). Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. . Proceedings of the National Academy of Sciences of the United States of America , 107 (15) , 6765-70.
  • Zhang, X., Leung, Y., & Ho, S. (2007). AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. . Oncogene , 26 (52) , 7346-54.
  • Stumpf M, Waskow C, Krötschel M, Essen D, Rodriguez P, Zhang X, Guyot B, Roeder RG and Borggrefe T. (2006). The Mediator Complex Functions as a Coactivator for GATA1 in Erythropoiesis via Subunit Med1/TRAP220 . Proc. Natl. Acad. Sci. , 103:18504-9.
  • Zhang, X., Krutchinsky, A., Fukuda, A., Chen, W., Yamamura, S., Chait, B. T., & Roeder, R. G. (2005). MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription . Mol Cell , 19 (1 ) , 89-100.
  • Zhang, X., Kolaczkowska, A., Devaux, F., Panwar, S. L., Hallstrom, T. C., Jacq, C., & Moye-Rowley, W. S. (2005). Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination . J Biol Chem , 280 (4 ) , 2759-70.
  • Le Crom, S., Devaux, F., Marc, P., Zhang, X., Moye-Rowley, W. S., & Jacq, C. (2002). New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system . Mol Cell Biol , 22 (8 ) , 2642-9.
  • Zhang, X., & Moye-Rowley, W. S. (2001). Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase . J Biol Chem , 276 (51 ) , 47844-52.
  • Zhang, X., Cui, Z., Miyakawa, T., & Moye-Rowley, W. S. (2001). Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae . J Biol Chem , 276 (12 ) , 8812-9.
  • Zhang, X., De Micheli, M., Coleman, S. T., Sanglard, D., & Moye-Rowley, W. S. (2000). Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p . Mol Microbiol , 36 (3 ) , 618-29.
  • Zhang, X., Ma, B., Shu, N., Chen, SZ, and Zhao, SY. (1997). Cloning the Gene Coding for Human Glial Cell Line-derived Neurotrophic Factor and its Expression in Escherichia Coli . Chinese Journal of Biotechnology , 13(4): 426-9.
  • Zhang, X., Chen, SZ, and Zhao, SY. (1996). The Gene Structure of Ciliary Neurotrophic Factor and its Receptor . Foreign Med. Sci. (Molecular Biology) , 18(5):225-9.

    Research Grants:

  • Breast Cancer Alliance . Masin Young Investigator Award, Completed.
  • Hormone Research Foundation. C.H. Li Memorial Scholar Award, Completed.
  • Susan G. Komen Breast Cancer Foundation . Postdoctoral Fellowship, Completed.
  • University of Cincinnati Cancer Center and the Department of Cancer and Cell Biology. Start-up, Active.
  • University of Cincinnati Cancer Center. Cancer Center Pilot Grant, PI, Completed.
  • American Heart Association. Beginning Grant-in-Aid, Completed.
  • Ride Cincinnati Foundation. Ride Cincinnati Award, Completed.
  • University of Cincinnati. CCTST Junior Investigator Award, Completed.
  • Ohio Cancer Research Associate. Seed Money, PI, Completed.
  • Department of Defense. BRCP Idea Award, PI, Completed.
  • Susan G. Komen For the Cure Foundation. Career Catalyst Award, PI, Active.
  • American Cancer Society. Research Scholar Grant, PI, Active.
  • 09BGIA2010011 American Heart Association - Great Rivers Affiliate. Novel Role of Transcriptional Coregulator MED1 in Muscle Metabolic Functions, PI, Closed.
  • SRS 007568 Ohio Cancer Research Associates. The ER/MED1 Axis and Mammary Stem/Progenitor Cells, PI, Closed.
  • KG110028 Susan G. Komen Breast Cancer Foundation. Crosstalk among MED1, ER and HER2: New Strategy to Overcome Endocrine Resistance in Breast Cancer, PI, Active.
  • RSG-12-268-01-CCG American Cancer Society - National Chapter. MED1: Molecular Mechanisms Regulating Cellular Senescence in Breast Cancer, PI, Active.
  • R01CA197865 National Institutes of Health. Role of MED1 in HER2-driven Breast Tumorigenesis, PI, Awarded.

Recent Awards/Honors:

  • Graduate Senator Travel Award. The University of Iowa, 2000
  • Masin Young Investigator Award. Breast Cancer Alliance, 2002
  • C.H. Li Memorial Scholar Award. Hormone Research Foundation, 2004
  • Postdoctoral Fellowship Award. Susan G. Komen Breast Cancer Foundation, 2005
  • Komen Mentorship Award. Susan G. Komen Breast Cancer Foundation, 2005
  • Ride Cincinnati Award. Ride Cincinnati Breast Cancer Foundation, 2010
  • IDEA award. Department of Defense BCRP, 2011
  • Career Catalyst Award . Susan G. Komen for the Cure Foundation, 2011
  • Research Scholar. American Cancer Society, 2012
  • Scientific Reviewer Panel, DOD Breast Cancer Research Program, 2014
  • Ad Hoc Reviewer, NIH Tumor Progression and Metastasis (TPM) Study Section, 2014
  • Grant Reviewer, Susan G. Komen for the Cure Foundation, 2014
  • Ad Hoc Reviewer. NIH Tumor Progression and Metastasis (TPM) Study Section, 2015